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Has been working since 2000

What is Attruby?

Attruby is a prescription medicine used to treat adults with a disease that affects the heart muscle called cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM), to reduce death and hospitalization related to heart problems

It is not known if Attruby is safe and effective in children

DISCUSSING ATTRUBY WITH YOUR DOCTOR

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ATTR-CARDIAC AMYLOIDOSIS

The TTR protein is an important protein that helps transport the hormone thyroxine (which regulates your metabolism) and retinol (vitamin A) in your body; hence the name TTR: “trans-thy-retin”

Stable TTR is healthy TTR

TTR is made up of 4 small proteins held tightly together through strong bonds.

Unstable TTR amyloid fibrils

When the bonds become unstable, TTR breaks down into abnormal proteins called amyloid fibrils, which then build up in the body, causing damage.

Amyloid fibrils are trouble

The buildup of amyloid fibrils thickens the walls of the heart. That means the heart cannot pump blood properly, causing the symptoms of heart failure

ABOUT

Attruby slows the buildup of abnormal proteins called amyloid fibrils When transthyretin (TTR) becomes unstable, it breaks down and reforms into abnormal proteins called amyloid fibrils. by attaching to TTR and stabilizing the bonds holding the protein together.

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Stable TTR means:

TTR remains whole, so it's less likely to break down and reform into the amyloid fibrils that cause ATTR-cardiac amyloidosis

How can I tell if Attruby is stabilizing my TTR?

  • Ask your doctor about a serum TTR test, also known as a prealbumin blood test
  • This test measures transthyretin (TTR) levels, also known as prealbumin. It measures overall health status. The higher your number is on the scale, the more stable TTR there is in your body.
  • Your doctor will help you understand how the test works and share what an appropriate level looks like for you
  • The higher your number on the scale, the more stable TTR there is in your body

Looking For Resource?

Whether you’re looking to learn about Attruby, better understand ATTR-CM, or hear from others like you, you’ve come to the right place

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Let’s Stay In Touch

Stay in the Know with the latest information about ATTR-Cm and Attruby.

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It Take A village

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Questions About Attruby?

Explore the most commonly asked questions about attruby from people living with ATTR-Cardiac.

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